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3-Iodoaniline: A Versatile Intermediate in Organic Synthesis
3-Iodoaniline is an organoiodine compound that belongs to the class of halogenated anilines. Structurally, it features an iodine atom substituted at the meta position of the benzene ring of aniline, giving it the chemical formula C6H6IN. This fine chemical serves as a valuable building block in the pharmaceutical, agrochemical, and materials industries, due to its reactivity and functional versatility.
One of the key applications of 3-iodoaniline lies in its role as an intermediate for synthesizing heterocycles and aryl-based structures through palladium-catalyzed coupling reactions. Reactions such as Suzuki, Heck, and Sonogashira couplings rely on compounds like 3-iodoaniline to construct complex aromatic systems, especially in drug discovery and materials research. The presence of the iodine atom makes it highly reactive towards these cross-coupling processes, offering high yields and selectivity.
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In pharmaceutical synthesis, 3-iodoaniline is used to create active pharmaceutical ingredients (APIs) and intermediates for anti-cancer, anti-inflammatory, and anti-viral drugs. The amino group on the…